Linked Life Data

2646200

Source:http://linkedlifedata.com/resource/pubmed/id/2646200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-4-11
pubmed:abstractText
The cellular derivation of Hodgkin (H) and Reed-Sternberg (RS) cells remains a controversial issue. A large body of conflicting results in the literature led to a variety of discordant speculations. The application of immunophenotyping, molecular biology and tissue culture provided additional means for investigations on the nature of H-RS cells. Using immunoenzymatic staining with monoclonal antibodies (McAbs) at the single cell level, H-RS cells from many, albeit not all cases, were shown to be positive for T- and/or B-cell markers; none of the cases were labelled by anti-myeloid or anti-monocyte/macrophage McAbs. A common feature of the otherwise heterogeneous immunoprofile is the expression of activation and proliferation antigens besides HLA-DR class II antigen and the X-hapten. Clonal rearrangements of T-cell receptor or immunoglobulin chain genes were found in 22 per cent of cases. The low frequency of positive samples might be due to the commonly low number of H-RS cells in the total population which can lay below the threshold of sensitivity for genotypic analysis. Several cell lines containing H-RS-like cells have been established. These cell lines have geno- and immunophenotypic characteristics of T- or B-cells, but lack properties of myeloid cells or monocytes/macrophages. In the absence of evidence in support of an origin from monocytes/macrophages or other non-lymphoid cells the here reviewed data, which are based on geno- and immunophenotypic analysis of fresh and cultured H-RS cells, provide a lead to a lymphoid derivation of H-RS cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0278-0232
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-113
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Is the Hodgkin cell a T- or B-lymphocyte? Recent evidence from geno- and immunophenotypic analysis and in-vitro cell lines.
pubmed:affiliation
University of Ulm School of Medicine, F.R.G.
pubmed:publicationType
Journal Article, Review