Linked Life Data

2645655

Source:http://linkedlifedata.com/resource/pubmed/id/2645655

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-4-6
pubmed:abstractText
Serologic diagnosis of HIV infection in infants and children is made especially difficult by the universal presence of maternal antibodies in blood during the first year of life, technical difficulties associated with the measurement of virus-specific IgM antibodies (except, perhaps, when the mother and, hence, the child have been very recently infected), and the weaker and more limited antibody reactivities revealed by Western blot analysis. Infants in the first year of life who develop reactivities on a Western blot that are different from those of their mothers are almost certainly infected. In addition, infants whose lymphocytes can be stimulated in vitro to produce HIV-specific antibodies of both the IgG and IgM isotypes and whose viral-specific antibodies can be found in the IgG3 subclass are also likely to be infected. Finally, children older than 15 months of age who remain seropositive by Western blot and who have both clinical and immunologic abnormalities consistent with HIV infection are also, doubtlessly, infected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0146-0005
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
16-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Virologic and serologic aspects of human immunodeficiency virus infection in infants and children.
pubmed:affiliation
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't