| pubmed-article:2645577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:2645577 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:2645577 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2645577 | pubmed:dateCreated | 1989-3-27 | lld:pubmed |
| pubmed-article:2645577 | pubmed:abstractText | Granulocyte/macrophage colony-stimulating factor (GM-CSF) is an acidic glycoprotein that stimulates hematopoiesis in vitro and in vivo. Despite a high degree of sequence homology, the GM-CSFs from human and murine sources fail to crossreact in their respective colony-forming assays. On the basis of this finding, a series of hybrid molecules containing various proportions of human- and murine-specific amino acid sequences were generated by recombinant DNA techniques and assayed for species-specific activity against human and murine marrow target cells. Two regions of GM-CSF, residues 38-48 and residues 95-111, were found to be critical for hematopoietic function. These regions are structurally characterized by an amphiphilic helix and by a disulfide-bonded loop, respectively, and are homologous in position in the human and murine growth factors. In addition, competition assays suggested that, together, these regions bind to the GM-CSF receptor. | lld:pubmed |
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| pubmed-article:2645577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2645577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2645577 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2645577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2645577 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2645577 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2645577 | pubmed:author | pubmed-author:BrownCC | lld:pubmed |
| pubmed-article:2645577 | pubmed:author | pubmed-author:KaushanskyKK | lld:pubmed |
| pubmed-article:2645577 | pubmed:author | pubmed-author:ShoemakerS... | lld:pubmed |
| pubmed-article:2645577 | pubmed:author | pubmed-author:AlfaroSS | lld:pubmed |
| pubmed-article:2645577 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2645577 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2645577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2645577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2645577 | pubmed:pagination | 1213-7 | lld:pubmed |
| pubmed-article:2645577 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2645577 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2645577 | pubmed:articleTitle | Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the activities of interspecies hybrid growth factors. | lld:pubmed |
| pubmed-article:2645577 | pubmed:affiliation | Division of Hematology, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:2645577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2645577 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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