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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1989-4-3
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pubmed:abstractText |
Forty-two monoclonal antibodies (mAbs) generated against nicotinic acetylcholine receptors (AChRs) from electric organ were tested for their ability to cross-react in the optic tectum of the frog Rana pipiens. Twenty-eight of the mAbs tested (67%) bound to the optic neuropil of the tectum as revealed by immunoperoxidase cytochemistry. The pattern of peroxidase stain for cross-reacting mAbs corresponded in position to a subset of the retinotectal projections. Electron microscopic examination revealed that peroxidase reaction product was associated with the surface of vesicle-containing profiles but not with synaptic sites. Removal of one retina resulted in the loss of immunoreactivity in the contralateral tectum. AChR-like immunoreactivity was also associated with the optic tract and optic nerve and with retinal ganglion cells. These results indicate that some classes of retinal ganglion cells bear AChR-like molecules on their surface. The existence of these molecules on ganglion cell axons and terminals seems the most likely explanation for the AChR-like immunoreactivity present in the tectum.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0270-6474
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
565-73
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2645388-Animals,
pubmed-meshheading:2645388-Antibodies, Monoclonal,
pubmed-meshheading:2645388-Axons,
pubmed-meshheading:2645388-Goldfish,
pubmed-meshheading:2645388-Immunoenzyme Techniques,
pubmed-meshheading:2645388-Rana pipiens,
pubmed-meshheading:2645388-Receptors, Nicotinic,
pubmed-meshheading:2645388-Retina,
pubmed-meshheading:2645388-Retinal Ganglion Cells,
pubmed-meshheading:2645388-Superior Colliculi,
pubmed-meshheading:2645388-Visual Pathways
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pubmed:year |
1989
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pubmed:articleTitle |
Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog.
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pubmed:affiliation |
Division of Biomedical Sciences, University of California, Riverside 92521.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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