Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-3-9
pubmed:abstractText
The kinetic changes induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) on hemopoietic cells were assessed in physiological conditions by administering GM-CSF (8 micrograms/kg per d) for 3 d to nine patients with solid tumors and normal bone marrow (BM), before chemotherapy. GM-CSF increased the number of circulating granulocytes and monocytes; platelets, erythrocytes, lymphocyte number, and subsets were unmodified. GM-CSF increased the percentage of BM S phase BFU-E (from 32 +/- 7 to 79 +/- 16%), day 14 colony-forming unit granulocyte-macrophage (CFU-GM) (from 43 +/- 20 to 82 +/- 11%) and day 7 CFU-GM (from 41 +/- 14 to 56 +/- 20%). The percentage of BM myeloblasts, promyelocytes, and myelocytes in S phase increased from 26 +/- 14 to 41 +/- 6%, and that of erythroblasts increased from 25 +/- 12 to 30 +/- 12%. This suggests that GM-CSF activates both erythroid and granulomonopoietic progenitors but that, among the morphologically recognizable BM precursors, only the granulomonopoietic lineage is a direct target of the molecule. GM-CSF increased the birth rate of cycling cells from 1.3 to 3.4 cells %/h and decreased the duration of the S phase from 14.3 to 9.1 h and the cell cycle time from 86 to 26 h. After treatment discontinuation, the number of circulating granulocytes and monocytes rapidly fell. The proportion of S phase BM cells dropped to values lower than pretreatment levels, suggesting a period of relative refractoriness to cell cycle-active antineoplastic agents.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-2897009, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-2931452, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-2984574, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3034976, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3096401, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3119759, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3260558, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3281007, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3296190, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3301903, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3484428, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3486413, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3487734, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3488777, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3497344, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3498941, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3500414, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3555651, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3877981, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-3923623, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-6185165, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-6206131, http://linkedlifedata.com/resource/pubmed/commentcorrection/2643633-7123245
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
551-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Kinetics of human hemopoietic cells after in vivo administration of granulocyte-macrophage colony-stimulating factor.
pubmed:affiliation
Dipartimento di Scienze Biomediche ed Oncologia Umana dell'Universitá, Torino, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't