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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4888
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|
pubmed:dateCreated |
1989-2-16
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|
pubmed:abstractText |
When grown in vitro, cells from Kaposi's sarcoma lesions of AIDS patients (AIDS-KS cells) constitutively release several growth promoting activities. When inoculated into nude mice, the AIDS-KS cells induce a KS-like lesion of mouse origin. Here it is shown that the AIDS-KS cells express messenger RNA for a complex mixture of cytokines that correlate with several of the biological activities of these cells. Basic fibroblast growth factor, which is a potent angiogenic factor, and interleukin-1 messenger RNAs are expressed at very high levels and seem to account for a large proportion of the activities, since their corresponding proteins are released in biologically active form into the culture media where they induce autocrine and paracrine growth effects.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
|
|
pubmed:issn |
0036-8075
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
13
|
|
pubmed:volume |
243
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
223-6
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pubmed:dateRevised |
2007-3-19
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|
pubmed:meshHeading |
pubmed-meshheading:2643161-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2643161-Biological Factors,
pubmed-meshheading:2643161-Cytokines,
pubmed-meshheading:2643161-Fibroblast Growth Factors,
pubmed-meshheading:2643161-Humans,
pubmed-meshheading:2643161-Interleukin-1,
pubmed-meshheading:2643161-RNA, Messenger,
pubmed-meshheading:2643161-Reference Values,
pubmed-meshheading:2643161-Sarcoma, Kaposi,
pubmed-meshheading:2643161-Transcription, Genetic,
pubmed-meshheading:2643161-Tumor Cells, Cultured
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pubmed:year |
1989
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|
pubmed:articleTitle |
AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects.
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pubmed:affiliation |
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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