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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1989-2-23
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pubmed:databankReference | |
pubmed:abstractText |
A 1.8 kb cDNA clone, Krev-1, with revertant-inducing activity on Kirsten sarcoma virus-transformed NIH/3T3 cells, has been isolated from a human fibroblast cDNA expression library. In Krev-1 transfectants, there is a correlation between the levels of specific mRNA and the degrees of suppression of the transformed phenotype. The cDNA encodes a protein of 21,000 daltons that unexpectedly shares around 50% amino acid identities with ras proteins. The Krev-1 homologs are found in mouse, rat, and chicken DNA, and their transcripts are ubiquitously expressed in many rat organs. Thus, the Krev-1 gene seems to play an important role(s) in a wide variety of tissues, and may be involved in the negative growth regulation of certain cell types.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
13
|
pubmed:volume |
56
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
77-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2642744-Amino Acid Sequence,
pubmed-meshheading:2642744-Animals,
pubmed-meshheading:2642744-Base Sequence,
pubmed-meshheading:2642744-Blotting, Northern,
pubmed-meshheading:2642744-Blotting, Southern,
pubmed-meshheading:2642744-Cell Transformation, Viral,
pubmed-meshheading:2642744-DNA,
pubmed-meshheading:2642744-Gene Expression Regulation,
pubmed-meshheading:2642744-Genes, ras,
pubmed-meshheading:2642744-Humans,
pubmed-meshheading:2642744-Multigene Family,
pubmed-meshheading:2642744-Rats
|
pubmed:year |
1989
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pubmed:articleTitle |
A ras-related gene with transformation suppressor activity.
|
pubmed:affiliation |
Laboratory of Molecular Oncology, Tsukuba Life Science Center, Ibaraki, Japan.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|