Linked Life Data

2641920

Source:http://linkedlifedata.com/resource/pubmed/id/2641920

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-10-12
pubmed:abstractText
Under normal physiological conditions, the central corneal epithelium is devoid of Ia+ Langerhans cells. However, a variety of stimuli can induce the migration of peripheral Langerhans cells into the central regions of the cornea. In the present study, Langerhans cell migration was induced by the instillation of either sterile latex beads or formalin-killed Staphylococcus aureus into shallow incisions in the central corneal epithelium. Langerhans cells could be detected in the central cornea as early as 24 hours following instillation of either latex beads or S. aureus and remained for at least 6 weeks. Phagocytosis of latex beads by corneal epithelial cells was demonstrated in vivo and in vitro. Moreover, phagocytosis of latex beads stimulated corneal epithelial cells to secrete increased amounts of interleukin-1 (21-83% increase). The centripetal migration of peripheral corneal Langerhans cells in response to phagocytosis of latex beads could be mimicked by injecting as little as 0.001 units of human purified interleukin-1 (IL-1) into the central corneal epithelium. The IL-1 induced chemotaxis could be blocked by coinjection of anti-IL-1 antibody but not irrelevant antibody. The findings indicate that the exclusion of Langerhans cells from the central corneal epithelium is a dynamic process that can be regulated by the resident corneal epithelial cells themselves and raises the possibility that corneal epithelial cells and Langerhans cells collaborate in antigen processing within this organ.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0896-0623
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-90
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Phagocytosis of particulate antigens by corneal epithelial cells stimulates interleukin-1 secretion and migration of Langerhans cells into the central cornea.
pubmed:affiliation
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't