Linked Life Data

2641819

Source:http://linkedlifedata.com/resource/pubmed/id/2641819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1990-10-11
pubmed:abstractText
Short-term effects of estradiol on gluconeogenesis, redox state and on the activities of the enzymes involved in NADPH production have been examined. Hepatocytes incubated with estradiol (10(-4)M) showed a decreased gluconeogenesis and an increased lactate/pyruvate ratio. The malic enzyme was found to be stimulated by 45%, whereas glucose-6-phosphate dehydrogenase and isocitrate dehydrogenase activities were not affected by the presence of the hormone. Estradiol produced selective inhibitions of glucose synthesis from various substrates and diminished malate dehydrogenase activity by 22%. The possibility that the estradiol-induced alterations here reported are related to the hormone catabolism itself in the liver is suggested. Other results in this work call attention to the importance of the vehicle used for the steroid dispersion. Propylene glycol markedly alters the metabolic state of liver cells and also antagonizes the modifications produced by estradiol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0034-9402
pubmed:author
pubmed:issnType
Print
pubmed:volume
45 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-24
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Metabolic changes due to the in vitro addition of estradiol in rat hepatocytes.
pubmed:affiliation
Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, Spain.
pubmed:publicationType
Journal Article