Linked Life Data

2641354

Source:http://linkedlifedata.com/resource/pubmed/id/2641354

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-9-25
pubmed:abstractText
Definitive epithelia suspended within type I collagen gel give rise to individual, freely migrating cells that express the mesenchymal phenotype. They become elongate in shape, invade collagenous matrices and develop abundant RER. We investigated whether mesenchyme-like cells that derive from lens epithelia retain the mesenchymal phenotype or revert to epithelial phenotype when cultured on basement membrane (BM). Mesenchyme-like cells placed on top of BM gel or lens capsule BM retain the elongate, bipolar morphology of mesenchymal cells. They migrate individually along and into the BM matrix. Mesenchyme-like cells on or in BM ultrastructurally resemble true mesenchymal cells. They extend pseudopodia and filopodia, exhibit a circumferential actin cortex, and contain well developed RER. Mesenchymal products, such as type I collagen, continue to be expressed. We conclude that the phenotype of mesenchyme-like cells derived from definitive epithelia is stable even in or on matrix known to promote the epithelial genetic program. Their behavior, thus, is similar to that of true (secondary) mesenchymal cells in the embryo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0214-6282
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
487-90
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Culture on basement membrane does not reverse the phenotype of lens derived mesenchyme-like cells.
pubmed:affiliation
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.