Linked Life Data

2640571

Source:http://linkedlifedata.com/resource/pubmed/id/2640571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1990-9-12
pubmed:abstractText
Spherical granules were prepared by loading a drug such as Indobufen on 40-45 mesh non-pareil seeds using air suspension coating technique (Wurster process, Uniglatt). The drug was added by spraying a formulated aqueous dispersion onto inert granules in different amounts employing two drug particle sizes with different surface areas. Then all active beads were coated with different thicknesses of polymeric film using the same fluid bed employed for loading the drug. The coatings were applied from aqueous dispersions (pseudolatex) of ethyl cellulose (Aquacoat ECD-30). In this system the drug diffusion is governed by the intrinsic pore network of the membrane. The finest drug particle size gave the fastest drug release rates. Moreover, the lowest drug loadings on inert granules resulted in the slowest drug release. Nevertheless thicker film coats involved a delay of drug release. Further preparations were made to evaluate the influence of changing the seed size to 25-30 mesh, loading the same amount of the drug and obtaining the increased surface are of the individual bead. In order to improve the drug release profile, the effect of changing diethylphthalate to the more water-soluble triethylcitrate and the addition of hydroxypropylmethyl cellulose or polysorbate 80 were also evaluated. In this case the drug diffusion is controlled by dissolution of a part of membrane leaving small channels of polymer coating.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-6648
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
373-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Influence of drug loading on coated beads release using air suspension technique.
pubmed:affiliation
Farmitalia Carlo Erba, Galenical Development Dept., Milan, Italy.
pubmed:publicationType
Journal Article