Linked Life Data

2638931

Source:http://linkedlifedata.com/resource/pubmed/id/2638931

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1990-8-13
pubmed:abstractText
The anti-inflammatory activity of a purified fraction of the rhizome of Wilbrandia (cf) verticillata, which contains two novel norcucurbitacin glucosides, is reported. The increase of vascular permeability induced by acetic acid in mice (N = 5) was inhibited 69% and 90% by 50 and 100 mg/kg of the purified fraction, po (P less than 0.01). Acetylsalicylic acid (200 mg/kg), po, inhibited the response by 62% under the same conditions (P less than 0.05). The purified fraction (100 mg/kg, po) also significantly inhibited paw swelling in the rat formaldehyde-induced arthritis model on 8 of 10 days and reduced the swelling by 63% on day 10. Dexamethasone (1 mg/kg, ip) was more effective than the extract under the same conditions. These data partially characterize the anti-inflammatory activity of the purified fraction from this plant which is used in Brazilian folk medicine for the treatment of arthritis and related disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1397-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Inhibition of formaldehyde-induced arthritis by a purified fraction prepared from Wilbrandia (cf) verticillata which contains novel norcucurbitacin glucosides.
pubmed:affiliation
Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Brasil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't