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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1990-6-8
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pubmed:abstractText |
The effect of vitamin E (D-alpha-tocopherol acetate) on glycosylated hemoglobin levels was investigated in streptozotocin-diabetic rats. The animals were divided into four groups: (a) Group 1: control group, (b) Group 2: diabetic group, (c) Group 3: diabetic group treated with low-dose vitamin E and (d) Group 4: diabetic group treated with high-dose vitamin E. Starting 24 hr after streptozotocin injections (60 mg/kg), Groups 3 and 4 received intraperitoneal injections of vitamin E on days 1, 4, 7, 11, 14, 18 and 21 at doses of 500 mg/kg and 1,000 mg/kg respectively. Vitamin E treatment did not prevent weight loss or improve glycemic control in diabetic animals but significantly suppressed the increase in glycosylated hemoglobin in Group 4 (7.7 +/- 0.6 mumols fructose/g hemoglobin versus 5.5 +/- 0.2 mumols fructose/g hemoglobin in Group 2 and Group 4 respectively). These levels were still significantly higher than the levels in healthy control group animals (2.6 +/- 0.1 mumols fructose/g hemoglobin). Further studies on the suppressive effect of vitamin E are warranted.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0265-5985
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-4
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pubmed:dateRevised |
2007-9-11
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pubmed:meshHeading |
pubmed-meshheading:2635093-Animals,
pubmed-meshheading:2635093-Blood Glucose,
pubmed-meshheading:2635093-Diabetes Mellitus, Experimental,
pubmed-meshheading:2635093-Hemoglobin A, Glycosylated,
pubmed-meshheading:2635093-Male,
pubmed-meshheading:2635093-Rats,
pubmed-meshheading:2635093-Rats, Inbred Strains,
pubmed-meshheading:2635093-Reference Values,
pubmed-meshheading:2635093-Vitamin E
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pubmed:year |
1989
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pubmed:articleTitle |
The effect of vitamin E on glycosylated hemoglobin levels in diabetic rats: a preliminary report.
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pubmed:affiliation |
Center for Experimental Medical Research and Application (DETAM) of Istanbul University, Turkey.
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pubmed:publicationType |
Journal Article
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