Linked Life Data

2634360

Source:http://linkedlifedata.com/resource/pubmed/id/2634360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1990-5-29
pubmed:abstractText
Three distinct anion exchangers are described that directly or indirectly mediate Cl- transport across the luminal membrane of the proximal tubule cell. Studies on the intact proximal tubule indicate that the Cl(-)-formate exchanger is a major mechanism for Cl- transport under physiologic conditions. As just discussed, the physiologic importance of the Cl(-)-oxalate and SO4 = (oxalate)-CO3 = exchangers mediating Cl- transport across the luminal membrane of the proximal tubule cell is currently unknown. These three anion exchangers are part of a larger group of at least eight distinct anion transporters in the proximal tubule that share with erythrocyte Band 3 the properties of stilbene sensitivity and/or the ability to mediate anion exchange. It is tempting to speculate that these proximal tubule anion transporters are members of a family of proteins structurally related to the prototypic anion exchanger, erythrocyte Band 3. If this is true, comparing the structures of these anion transporters with each other and with Band 3 should provide important insight into the molecular basis for differences in substrate and inhibitor specificity within this family of transport proteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
574
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-101
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Heterogeneity of anion exchangers mediating chloride transport in the proximal tubule.
pubmed:affiliation
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.