Linked Life Data

2632614

Source:http://linkedlifedata.com/resource/pubmed/id/2632614

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1990-5-11
pubmed:abstractText
Functional changes of the T-cell immune system in submandibularectomized (SMx) male mice of CBA/H strain were analyzed three or four weeks after treatment. Thymuses and spleens were weighed and morphologically examined by light microscopy. We tested proliferation rates of thymocytes and splenocytes (stimulated by Con A and PHA) and cytotoxic activity of T lymphocytes in SMx, CBA/H (H-2k) mice by means of the rejection test of allogeneic skin graft (Balb/c, H-2d) and a microcytoxicity to allo-antigens of EL-4 tumor cells (H-2b). Results showed a reduction of the weights of the thymus and spleen. However, there was increased functional capacity of the thymocytes--expressed as increased proliferation rates of the stimulated thymocytes, increased microcytotoxicity to allo-antigens of EL-4 tumor cells in vitro, and a reduction of the survival period of skin allografts in vivo. No morphological changes other than a reduction in both the cortex and medullar of the thymus were observed. The subpopulational changes within the T-cell system because of SMx indicate that the morphological atrophy could be just a consequence of SMx.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-0345
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1252-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The effects of submandibularectomy on the thymus and T-cell system of mice.
pubmed:affiliation
Department of Oral Biochemistry, Fukuoka Dental College, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't