Linked Life Data

2632528

Source:http://linkedlifedata.com/resource/pubmed/id/2632528

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1990-5-21
pubmed:abstractText
Renal function was assessed by determining three hour creatinine clearance (THCC) values in 20 patients (13 males, seven females; age 16-55 years) of nutritional iron deficiency anaemia. Mean transferrin saturation was 4.6% (SD 2.3). Haemoglobin and THCC were determined twice at the interval of three days before therapy. All patients received total dose iron-dextran intravenously. Three days after therapy, haemoglobin and THCC were determined again. Paired 't' test was used to determine the significance of the difference. There was no significant difference between the two pretherapy mean haemoglobin values (6.1 +/- 3.5 g/dl and 5.6 +/- 4.5 g/dl; p greater than 0.2), and the two pretherapy mean THCC values (67.2 +/- 36.9 ml/min and 70.3 +/- 22.8 ml/min; p greater than 0.5). There was no significant difference (p greater than 0.5) between pre-and post-therapy mean haemoglobin levels (6.6 +/- 2.2 g/dl). The difference between the pre-therapy and post-therapy THCC (95.3 +/- 34.0 ml/min) was statistically significant (p less than 0.01). It is concluded on the basis of these results that renal function as measured by THCC is impaired in iron deficiency anaemia, and it improves significantly within three days of total dose intravenous iron-dextran therapy when there is no significant increase in haemoglobin value. This is likely to represent the effect of iron at the tissue level independent of the anaemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0004-5772
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
685-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effect of iron deficiency on renal function.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't