Linked Life Data

2625775

Source:http://linkedlifedata.com/resource/pubmed/id/2625775

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-4-11
pubmed:abstractText
Experiments were performed to quantitate the delivery of two drugs into the eye following hyperthermia. The drugs, cytosine arabinoside and 5-fluorouridine, were encapsulated in temperature-sensitive liposomes. After systemic injection of the liposome-encapsulated drug, microwave hyperthermia was applied to the superior limbus of rabbit eyes in an attempt to locally release the drug. Samples of aqueous humor and vitreous showed significantly higher drug levels in the heated versus the unheated eyes. Histology of the heated eyes showed no significant damage to ocular structures at the power level used to release the entrapped drug. Heating at higher power levels did damage the eye, confirming earlier studies. The potential uses and limitations of this drug delivery modality are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-5155
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-12
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Hyperthermia and temperature-sensitive liposomes: selective delivery of drugs into the eye.
pubmed:affiliation
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Oreleans 70112.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.