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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-11-24
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pubmed:abstractText |
We have recorded membrane impedance and voltage noise in the pacemaker range of potentials (-70 to -59 mV) from spheroidal aggregates of 7-d embryonic chick ventricle cells made quiescent by exposure to tetrodotoxin in medium containing 4.5 mM K+. The input capacitance is proportional to aggregate volume and therefore to total membrane area. The specific membrane capacitance is 1.24 microF/cm2. The input resistance at constant potential is inversely proportional to aggregate volume and therefore to total membrane area. The specific membrane resistance in 18 k omega . cm2 at -70 mV and increases to 81 k omega . cm2 at -59 mV. The RC time constant is 22 ms at -70 mV and increases to 146 ms at -59 mV. The aggregate transmembrane small-signal impedance can be represented by a parallel RC circuit itself in parallel with an inductive branch consisting of a resistor (rL) and an inductor (L) in series. The time constant of the inductive branch (L/rL) is 340 ms, and is only weakly dependent on potential. Correlation functions of aggregate voltage noise and the impedance data were modeled by a population of channels with simple open-close kinetics. The time constant of a channel (tau s) derived from the noise analysis is 300 ms. The low frequency limit of the pacemaker current noise (SI[0]), derived from the voltage noise and impedance, increases from 10(-20) A2/Hz . cm2 at -67 mV to 10(-19) A2/Hz . cm2 at -61 mV.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-1033292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-1086902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-1087643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-1117281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-1151828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-1185607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-1238398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-12991237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-13773012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-262383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-304052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-436747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-438769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-4407444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-4566209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-4683099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-4697746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-5044577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-5044583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-5424376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-5435782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-5476811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-5639799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-5972158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/262547-68708
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-84
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1979
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pubmed:articleTitle |
Current noise parameters derived from voltage noise and impedance in embryonic heart cell aggregates.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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