Linked Life Data

2625237

Source:http://linkedlifedata.com/resource/pubmed/id/2625237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1990-3-30
pubmed:abstractText
According to Stass et al. the percentage of a lineage switch occurs in 6.7%-8.6% of patients with acute leukemia. Mostly, a conversion from the lymphoid to the myeloid phenotype is seen. In our three cases we found two switches from the myeloid to the lymphoid phenotype and only one from lymphoid to myeloid. This lineage switch is seen in relapsing and resistant leukemia cases. Different hypotheses have been discussed concerning the phenotype switch. Cytostatic chemotherapy may eradicate one leukemic cell clone, allowing another one to proliferate. Otherwise, the leukemic transformed stem cell could be influenced by the chemotherapy, resulting in a change of the differentiation program of the cell and following with a switch of marker expression. Perhaps there is some clinical importance to monitoring the phenotype switch in order to administer the best treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0171-7111
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-3
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Phenotype switch in acute leukemia patients after intensive chemotherapy.
pubmed:affiliation
Department of Internal Medicine, University Hospital Charité, Humboldt-Universität Berlin, German Democratic Republic.
pubmed:publicationType
Journal Article, Case Reports