Linked Life Data

2623046

Source:http://linkedlifedata.com/resource/pubmed/id/2623046

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-3-27
pubmed:abstractText
Previous experiments have shown that the potentiation of physostigmine-induced yawning by nifedipine is abolished by sham-lesioning procedures in rats, whereas the nifedipine potentiation of apomorphine-induced yawning is unaffected. The present results demonstrate that either the presurgical drug treatment (desmethylimipramine and pentobarbital) or 7 days isolation was alone sufficient to reduce the yawning response to physostigmine and abolish its potentiation by nifedipine. The sham-lesioned rats responded normally to a combination of apomorphine and nifedipine. These results suggest that the stress associated with standard operative procedures can differentially affect drug interactions with yawning induced by either apomorphine or physostigmine and that caution should be exercised when interpreting results from animals that have been similarly stressed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
915-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The effect of pre- and postoperative procedures on physostigmine- and apomorphine-induced yawning in rats.
pubmed:affiliation
Merrell Dow Research Institute, Strasbourg, France.
pubmed:publicationType
Journal Article