Linked Life Data

2619737

Source:http://linkedlifedata.com/resource/pubmed/id/2619737

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1990-3-7
pubmed:abstractText
The effect of moderate hypobaric hypoxia and almitrine bismesylate (almitrine) on salt and water intake was investigated in carotid body denervated (CBD) and sham-operated (SO) spontaneously hypertensive rats (SHR). The animals were kept singly in metabolic cages and given free access to food, water and a 2.5% NaCl-solution. Oral administration of almitrine and exposure to hypobaric hypoxia for five days evoked a suppression of voluntary salt intake in SO-SHR, but not in CBD-SHR. Exposure of SO and CBD-SHR to hypobaric hypoxia resulted in a significant decrease in water intake in animals of both groups on the first day of hypoxia. Stimulation of the arterial chemoreceptors by almitrine induced no change in water intake similar to that evoked by hypobaric hypoxia. These results prove that stimulation of the arterial chemoreceptors has a direct effect on salt appetite but not on water intake in SHR.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
689-95
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effect of hypobaric hypoxia and almitrine on voluntary salt and water intake in carotid body denervated spontaneously hypertensive rats.
pubmed:affiliation
Institute of Physiology, Wilhelm-Pieck University, GDR, Rostock.
pubmed:publicationType
Journal Article