Linked Life Data

2618978

Source:http://linkedlifedata.com/resource/pubmed/id/2618978

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-3-12
pubmed:abstractText
Two cases of children with essential thrombocythemia (ET) with the presence of a Philadelphia chromosome (Ph1) are presented and discussed. Diagnosis was based on their clinical presentation and marked primary thrombocytosis. The site of the Ph1 translocation, as detected by a 1.2-kb bcr genomic probe, differed in the two patients. These cases, along with other reported cases of Ph1-positive ET in the literature, suggest that the presence of the Ph1 cannot be used to rule out a diagnosis of ET. Additionally, the differing translocation sites in these cases suggests that the exact translocation site may not be significant in determining which cell lineage will predominate in a Ph1-positive myeloproliferative disorder.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-8562
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
433-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Philadelphia-chromosome positive essential thrombocythemia. Two cases in children.
pubmed:affiliation
Division of Pediatric Oncology, Johns Hopkins Hospital, Baltimore, MD 21205.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't