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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1990-3-1
|
| pubmed:abstractText |
Sera from individuals living in 2 areas endemic for Schistosoma mansoni in Minas Gerais, Brazil were assayed for the presence of antibodies against paramyosin and glutathione-S-transferase (GST), molecules previously implicated as vaccine immunogens from studies in laboratory hosts. A group was identified consisting of subjects who were stool-negative and had no record of previous infection but who were seropositive by enzyme-linked immunosorbent assay against crude adult worm antigen (SWAP). These individuals had anti-paramyosin antibody levels which were dramatically elevated with respect to those measured in infected (stool-positive) individuals living in the same endemic area. In contrast, the same 2 groups of stool-positive and stool-negative subjects could not be distinguished on the basis of their seroreactivity to either GST or SWAP. After chemotherapy, anti-paramyosin antibodies rose above pre-treatment levels and remained elevated in those individuals who became stool-negative. In contrast, anti-paramyosin antibodies decreased to pretreatment values in drug-treated individuals who failed to show complete parasitological cure. These results suggest that the immune response of humans to paramyosin may play a role in natural resistance to schistosome infection, and that an elevated antibody level against this antigen may be a useful correlate of drug-induced cure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0035-9203
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
798-804
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2617649-Adolescent,
pubmed-meshheading:2617649-Adult,
pubmed-meshheading:2617649-Aged,
pubmed-meshheading:2617649-Animals,
pubmed-meshheading:2617649-Antibodies,
pubmed-meshheading:2617649-Antibodies, Helminth,
pubmed-meshheading:2617649-Antibody Formation,
pubmed-meshheading:2617649-Brazil,
pubmed-meshheading:2617649-Child,
pubmed-meshheading:2617649-Child, Preschool,
pubmed-meshheading:2617649-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2617649-Feces,
pubmed-meshheading:2617649-Female,
pubmed-meshheading:2617649-Glutathione Transferase,
pubmed-meshheading:2617649-Humans,
pubmed-meshheading:2617649-Male,
pubmed-meshheading:2617649-Middle Aged,
pubmed-meshheading:2617649-Schistosoma mansoni,
pubmed-meshheading:2617649-Tropomyosin
|
| pubmed:articleTitle |
The human immune response to defined immunogens of Schistosoma mansoni: elevated antibody levels to paramyosin in stool-negative individuals from two endemic areas in Brazil.
|
| pubmed:affiliation |
Centro de Pesquisas Rene Rachou, Fundaçao Oswaldo Cruz, Minas Gerais, Brazil.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|