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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1990-3-15
|
| pubmed:abstractText |
The incidence of strains producing transferable beta-lactamases capable of hydrolyzing third generation cephalosporins or aminothiazole-oximino substituted monobactams in five Buenos Aires hospitals during a four month period was studied. These enzymes were categorized by 1) MIC greater than or equal to 1 mg/l for third generation cephalosporins; 2) MIC less than 0.06 mg/l for third generation cephalosporins combined with clavulanic acid or sulbactam; 3) sensitivity to imipenem or cephamycins (excluding permeability mutants); and 4) transferable resistance by conjugation. Beta-lactamases hydrolyzing aminothiazole-oximino substituted monobactams were produced by 17.2% of Enterobacteriaceae from intensive care unit patients; 3.6% from inpatients of other units and 1.2% from outpatients. Producers were mainly Klebsiella spp. (45/46) resistant to aminoglycosides (most of them AAC 3'-AAC 6' producers). Three strains had a an isoelectric point of 6.0, two of 6.5 and three of 7.7. TEM-1 beta-lactamase (isoelectric point 5.4) was detected in 6/8 strains. An inocolum effect was observed in 40/46 strains. A Klebsiella pneumoniae strain preserved since 1982 also produced a transferable beta-lactamase hydrolyzing aminothiazole-oximino substituted monobactams.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-8126
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
434-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2613338-Adult,
pubmed-meshheading:2613338-Argentina,
pubmed-meshheading:2613338-Bacterial Infections,
pubmed-meshheading:2613338-Conjugation, Genetic,
pubmed-meshheading:2613338-Drug Resistance, Microbial,
pubmed-meshheading:2613338-Humans,
pubmed-meshheading:2613338-Hydrolysis,
pubmed-meshheading:2613338-Incidence,
pubmed-meshheading:2613338-Infant, Newborn,
pubmed-meshheading:2613338-Microbial Sensitivity Tests,
pubmed-meshheading:2613338-beta-Lactamases
|
| pubmed:articleTitle |
Incidence of strains producing extended spectrum beta-lactamases in Argentina.
|
| pubmed:affiliation |
Department of Diseases and Clinical Microbiology, Catholic University, Buenos Aires, Argentina.
|
| pubmed:publicationType |
Journal Article
|