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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1990-3-2
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pubmed:abstractText |
The maturation of the N-acetyltransferase-dependent AFMU production from caffeine was studied during infancy. The group of children (N = 14) consisted of 4 premature newborn infants and ten 1-19 month-old infants who received caffeine citrate solution for the treatment and prevention of apnea. Caffeine, AFMU, 1X and 9 other metabolites were measured in urine using HPLC. The AFMU/1X ratio did not vary significantly in this population with increasing age. In one of the infants serially studied, the AFMU/1X ratio increased dramatically between 6 and 12 months of age. This observation suggests that the maturation of N-acetyltransferase activity is not completed before 1 year of age implying that acetylator status cannot reliably be determined before that age. Patients studied before 1 year of age whose AFMU/1X ratio was below 0.4 may be either true slow acetylators or still immature fast acetylators.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0767-3981
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
589-95
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2613160-Acetylation,
pubmed-meshheading:2613160-Caffeine,
pubmed-meshheading:2613160-Chromatography, High Pressure Liquid,
pubmed-meshheading:2613160-Humans,
pubmed-meshheading:2613160-Indicators and Reagents,
pubmed-meshheading:2613160-Infant,
pubmed-meshheading:2613160-Infant, Newborn,
pubmed-meshheading:2613160-Infant, Premature,
pubmed-meshheading:2613160-Phenotype,
pubmed-meshheading:2613160-Uracil
|
pubmed:year |
1989
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pubmed:articleTitle |
Maturation of AFMU excretion in infants.
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pubmed:affiliation |
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent-de-Paul, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|