| pubmed-article:2612905 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2612905 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:2612905 | lifeskim:mentions | umls-concept:C0162796 | lld:lifeskim |
| pubmed-article:2612905 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2612905 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2612905 | pubmed:dateCreated | 1990-3-1 | lld:pubmed |
| pubmed-article:2612905 | pubmed:abstractText | The RNA branch formed during pre-mRNA splicing occurs at a wide variety of sequences (branch sites) in different mammalian pre-mRNAs. U2 small nuclear ribonucleoprotein (snRNP) binds to the pre-mRNA branch site following the interaction of a protein, U2AF, with the 3' splice site/polypyrimidine tract. Here we show that despite the variability of mammalian branch sites, U2 snRNP has a sequence-specific RNA-binding activity. Thus, RNA branch formation is regulated by two sequence-specific interactions: U2AF with the 3' splice site/polypyrimidine tract, and U2 snRNP with the branch site. The affinity of the branch site for U2 snRNP affects the efficiency of spliceosome assembly and splicing. | lld:pubmed |
| pubmed-article:2612905 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2612905 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2612905 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2612905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2612905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2612905 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2612905 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2612905 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:2612905 | pubmed:author | pubmed-author:GreenM RMR | lld:pubmed |
| pubmed-article:2612905 | pubmed:author | pubmed-author:NelsonK KKK | lld:pubmed |
| pubmed-article:2612905 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2612905 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:2612905 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2612905 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2612905 | pubmed:pagination | 1562-71 | lld:pubmed |
| pubmed-article:2612905 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2612905 | pubmed:meshHeading | pubmed-meshheading:2612905-... | lld:pubmed |
| pubmed-article:2612905 | pubmed:meshHeading | pubmed-meshheading:2612905-... | lld:pubmed |
| pubmed-article:2612905 | pubmed:meshHeading | pubmed-meshheading:2612905-... | lld:pubmed |
| pubmed-article:2612905 | pubmed:meshHeading | pubmed-meshheading:2612905-... | lld:pubmed |
| pubmed-article:2612905 | pubmed:meshHeading | pubmed-meshheading:2612905-... | lld:pubmed |
| pubmed-article:2612905 | pubmed:meshHeading | pubmed-meshheading:2612905-... | lld:pubmed |
| pubmed-article:2612905 | pubmed:meshHeading | pubmed-meshheading:2612905-... | lld:pubmed |
| pubmed-article:2612905 | pubmed:meshHeading | pubmed-meshheading:2612905-... | lld:pubmed |
| pubmed-article:2612905 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2612905 | pubmed:articleTitle | Mammalian U2 snRNP has a sequence-specific RNA-binding activity. | lld:pubmed |
| pubmed-article:2612905 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138. | lld:pubmed |
| pubmed-article:2612905 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2612905 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2612905 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2612905 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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