Linked Life Data

2612130

Source:http://linkedlifedata.com/resource/pubmed/id/2612130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-3-7
pubmed:abstractText
The susceptibilities of 258 Bacteroides fragilis group isolates and 42 other Bacteroides species isolates against cefoperazone, cefoperazone/sulbactam (2:1 ratio) and selected other antimicrobials were determined by broth microdilution method. All isolates were susceptible to cefoperazone/sulbactam, ampicillin/sulbactam, ticarcillin/clavulanate, metronidazole, and imipenem. Other antibiotics showed variables levels of resistance (5-30%). Killing curves with the cef/sulb against selected B. fragilis group isolates were performed and showed excellent bactericidal activity at two to four times the minimum inhibitory concentration (MIC) after 12 hr incubation, even against the isolates with high cefoperazone MICs (greater than or equal to 64 micrograms ml). There was no regrowth at 24 hr. Cefoperazone/sulbactam is a compound with excellent inhibitory and bactericidal activity against B. fragilis group isolates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0732-8893
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
421-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
In vitro comparison of cefoperazone/sulbactam with selected antimicrobials against 300 bacteroides isolates. Inhibitory activity and time-kill kinetic studies.
pubmed:affiliation
Clinical Microbiology Laboratory, Methodist Hospitals of Memphis, Tennessee.
pubmed:publicationType
Journal Article, Comparative Study