Linked Life Data

2611991

Source:http://linkedlifedata.com/resource/pubmed/id/2611991

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1990-2-23
pubmed:abstractText
We have developed a rapid and sensitive high-performance liquid chromatographic method for the determination of low concentrations of the stereoisomers of methamphetamine (MAMP) and the demethylated metabolite, amphetamine (AMP). The acetyl derivatives of the stereoisomers (d and l-form) of MAMP and AMP smuggled by gangsters or extracted from biological specimens (hair) of drug addicts were clearly separated on two stereoisomer-analytical columns (Chiralcel OB and OJ, Daicel Ind. Co., Japan) connected in series at 50 degrees C. The mobile phase was a mixture of n-hexane and isopropanol (9:1, v/v) and the UV detector was set at 220 nm. The practical limit of sensitivity for the analysis was 62.5 ng of the stereoisomers of MAMP and AMP. Our analytical method for MAMP and AMP in human hair is very useful for the diagnosis of abuse of the drug. The determination of the d/l ratio of MAMP and AMP (the fingerprint of MAMP and AMP) is applicable to the investigation of smuggling routes of these drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0009-9120
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
439-42
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
A new analytical method for stereoisomers of methamphetamine and amphetamine and its application to forensic toxicology.
pubmed:affiliation
Faculty of Bioscience, School of Hygienic Sciences, Kitasato University, Kanagawa, Japan.
pubmed:publicationType
Journal Article