Linked Life Data

2611963

Source:http://linkedlifedata.com/resource/pubmed/id/2611963

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1990-3-8
pubmed:abstractText
Dolichol content and the effects of dolichol in vitro on synaptic plasma membrane (SPM) structure of different age groups of C57BL/6NNIA mice were examined. SPM of aged mice had higher amounts of dolichol as compared to younger animals. Age differences also were observed in dolichol isoprenologue distribution. In older animals, dolichol isoprenologue chain length was shifted towards shorter chain length values. The structure of SPM was determined by differential polarized phase fluorometry of 1,6-diphenyl-1,3,5-hexatriene (DPH). The SPM of old mice were more rigid, as indicated by higher limiting anisotropy, than those of young mice. Dolichol administered in vitro to SPM fluidized the membranes. However, dolichol administered in vitro fluidized SPM of younger mice significantly more than SPM of aged mice. The functional role of increased dolichol content in aged individuals is not known. Dolichol may act to regulate membrane fluidity of aged animals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0009-3084
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-26
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Membrane properties of dolichol in different age groups of mice.
pubmed:affiliation
Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, St. Louis, MO.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.