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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1990-3-14
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pubmed:abstractText |
1. To elucidate the mechanisms of the powerful and long-lasting hypotension produced by platelet activating factor (PAF), its effects on perfusion pressure in the perfused mesenteric arterial bed of the rat were examined. 2. Infusion of PAF (10(-11) to 3 x 10(-10) M; EC50 = 4.0 x 10(-11) M; 95%CL = 1.6 x 10(-11) - 9.4 x 10(-11) M) and acetylcholine (ACh) (10(-10) to 10(-6) M; EC50 = 3.0 +/- 0.1 x 10(-9) M) produced marked concentration-dependent vasodilatations which were significantly inhibited by treatment with detergents (0.1% Triton X-100 for 30 s or 0.3% CHAPS for 90 s). 3. Pretreatment with CV-6209, a PAF antagonist, inhibited PAF- but not ACh-induced vasodilation. 4. Treatment with indomethacin (10(-6) M) had no effect on PAF- or ACh-induced vasodilatation. 5. These results demonstrate that extremely low concentrations of PAF produce vasodilatation of resistance vessels through the release of endothelium-derived relaxing factor (EDRF). This may account for the strong hypotension produced by PAF in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-14296957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-2570630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-2986648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-3019921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-3265342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-335560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-3366477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-3612533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-3625454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-377104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-385330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-3922777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-4009403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-489536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-6144557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-6203480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-6253831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-6415166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-6668545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-6726619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611496-6733593
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1360-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2611496-Acetylcholine,
pubmed-meshheading:2611496-Animals,
pubmed-meshheading:2611496-Detergents,
pubmed-meshheading:2611496-Endothelium, Vascular,
pubmed-meshheading:2611496-Male,
pubmed-meshheading:2611496-Muscle Relaxation,
pubmed-meshheading:2611496-Platelet Activating Factor,
pubmed-meshheading:2611496-Pyridinium Compounds,
pubmed-meshheading:2611496-Rats,
pubmed-meshheading:2611496-Rats, Inbred Strains,
pubmed-meshheading:2611496-Splanchnic Circulation,
pubmed-meshheading:2611496-Vascular Resistance
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pubmed:year |
1989
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pubmed:articleTitle |
Endothelium-dependent vasodilator effects of platelet activating factor on rat resistance vessels.
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pubmed:affiliation |
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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