| pubmed-article:2611085 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2611085 | lifeskim:mentions | umls-concept:C0009214 | lld:lifeskim |
| pubmed-article:2611085 | lifeskim:mentions | umls-concept:C0682086 | lld:lifeskim |
| pubmed-article:2611085 | lifeskim:mentions | umls-concept:C0598864 | lld:lifeskim |
| pubmed-article:2611085 | lifeskim:mentions | umls-concept:C1880989 | lld:lifeskim |
| pubmed-article:2611085 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:2611085 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:2611085 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2611085 | pubmed:dateCreated | 1990-3-6 | lld:pubmed |
| pubmed-article:2611085 | pubmed:abstractText | 1. The 8 h urinary excretion of codeine and seven of its metabolites was compared in 149 healthy Swedish Caucasians and 133 healthy Chinese following a single oral dose of 25 mg codeine phosphate. 2. The total 8 h urinary recovery of drug-related material was 74 +/- 24% in the Caucasians and 60 +/- 14% in the Chinese (P less than 0.001). The excretion of unchanged codeine was significantly higher in the Chinese (7.2%) compared with the Caucasians (4.3%, P less than 0.001). 3. The Caucasians excreted significantly greater proportions of codeine-6-glucuronide (C6G) (62%) than the Chinese (44%) (P less than 0.001). The frequency distribution of the log metabolic ratio (MR) for glucuronidation (codeine/C6G) was shifted towards higher values in the Chinese population. Males in both groups and Chinese smokers had significantly lower glucuronidation MRs than females and non-smokers in the respective populations (P less than 0.001). 4. The frequency distribution of the MR for O-demethylation (codeine/morphine (M) + M-3 and M-6-glucuronide (M3G and M6G) + normorphine (NM) was highly skewed in the Caucasians, suggestive of a bimodal distribution. There was a 160-fold interindividual variation in this MR. A unimodal distribution of the log O-demethylation MR was observed in Chinese. The Caucasians excreted less M and more M6G than did the Chinese (P less than 0.001). 5. Significantly more norcodeine (NC) and less NC-glucuronide (NCG) were excreted in the Chinese compared with the Caucasians (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:2611085 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2611085 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2611085 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2611085 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2611085 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2611085 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:2611085 | pubmed:author | pubmed-author:SjöqvistFF | lld:pubmed |
| pubmed-article:2611085 | pubmed:author | pubmed-author:SäweJJ | lld:pubmed |
| pubmed-article:2611085 | pubmed:author | pubmed-author:SvenssonJ OJO | lld:pubmed |
| pubmed-article:2611085 | pubmed:author | pubmed-author:YueQ YQY | lld:pubmed |
| pubmed-article:2611085 | pubmed:author | pubmed-author:AltHH | lld:pubmed |
| pubmed-article:2611085 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2611085 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:2611085 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2611085 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2611085 | pubmed:pagination | 629-37 | lld:pubmed |
| pubmed-article:2611085 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2611085 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2611085 | pubmed:articleTitle | Interindividual and interethnic differences in the demethylation and glucuronidation of codeine. | lld:pubmed |
| pubmed-article:2611085 | pubmed:affiliation | Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden. | lld:pubmed |
| pubmed-article:2611085 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2611085 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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