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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1990-3-6
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pubmed:abstractText |
1. The 8 h urinary excretion of codeine and seven of its metabolites was compared in 149 healthy Swedish Caucasians and 133 healthy Chinese following a single oral dose of 25 mg codeine phosphate. 2. The total 8 h urinary recovery of drug-related material was 74 +/- 24% in the Caucasians and 60 +/- 14% in the Chinese (P less than 0.001). The excretion of unchanged codeine was significantly higher in the Chinese (7.2%) compared with the Caucasians (4.3%, P less than 0.001). 3. The Caucasians excreted significantly greater proportions of codeine-6-glucuronide (C6G) (62%) than the Chinese (44%) (P less than 0.001). The frequency distribution of the log metabolic ratio (MR) for glucuronidation (codeine/C6G) was shifted towards higher values in the Chinese population. Males in both groups and Chinese smokers had significantly lower glucuronidation MRs than females and non-smokers in the respective populations (P less than 0.001). 4. The frequency distribution of the MR for O-demethylation (codeine/morphine (M) + M-3 and M-6-glucuronide (M3G and M6G) + normorphine (NM) was highly skewed in the Caucasians, suggestive of a bimodal distribution. There was a 160-fold interindividual variation in this MR. A unimodal distribution of the log O-demethylation MR was observed in Chinese. The Caucasians excreted less M and more M6G than did the Chinese (P less than 0.001). 5. Significantly more norcodeine (NC) and less NC-glucuronide (NCG) were excreted in the Chinese compared with the Caucasians (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-13243236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-13588540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-14060774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-2536896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-2889047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-2895346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-2902373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-2915667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-3105543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-3358767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-3556375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-3567011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-4042522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-4042523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-4144623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-6416284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-7094509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-7107787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-7381862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-7397056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2611085-7434400
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
629-37
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2611085-Adolescent,
pubmed-meshheading:2611085-Adult,
pubmed-meshheading:2611085-Aged,
pubmed-meshheading:2611085-Asian Continental Ancestry Group,
pubmed-meshheading:2611085-Codeine,
pubmed-meshheading:2611085-Contraceptives, Oral, Hormonal,
pubmed-meshheading:2611085-Dealkylation,
pubmed-meshheading:2611085-Ethnic Groups,
pubmed-meshheading:2611085-European Continental Ancestry Group,
pubmed-meshheading:2611085-Female,
pubmed-meshheading:2611085-Glucuronates,
pubmed-meshheading:2611085-Humans,
pubmed-meshheading:2611085-Individuality,
pubmed-meshheading:2611085-Male,
pubmed-meshheading:2611085-Middle Aged,
pubmed-meshheading:2611085-Sex Factors,
pubmed-meshheading:2611085-Smoking
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pubmed:year |
1989
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pubmed:articleTitle |
Interindividual and interethnic differences in the demethylation and glucuronidation of codeine.
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pubmed:affiliation |
Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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