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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-2-22
|
| pubmed:abstractText |
Functional and metabolic parameters of thoracic aorta from Watanabe heritable hyperlipemic (WHHL) rabbits (aged 11-14 months) were investigated in vitro. The aortic preparations, normally responsive to noradrenaline, showed a diminished response to the endothelium-dependent agent, acetylcholine, in comparison with control preparations from age-matched New Zealand rabbits (maximal relaxation: 33 +/- 4% in WHHL vs. 52 +/- 2% in controls: P less than 0.005). ATP relaxant effect (only partially endothelium-dependent) was unimpaired in WHHL aorta, and it was much higher than in controls (maximal response: 63 +/- 6% vs. 37 +/- 3%, respectively; P less than 0.005). The response to NaNO2, an endothelium-independent relaxant, was unchanged in WHHL aortas. Acetylcholine-induced response was found to be inversely related to the degree of total cholesterol infiltration in aorta (r = -0.62, P less than 0.05). No correlation was observed between either total serum cholesterol or triglycerides and ACh-induced response. Furthermore, the concentration of adenine nucleotides and nucleosides in the aortic tissue of WHHL rabbits was lower than in controls, indicating a loss of energy balance. The results indicate a functional damage induced by genetic hyperlipidemia on endothelium-dependent relaxation and an impairment of energy-rich phosphate metabolism of the aortic wall. The relationship between functional and metabolic parameters is not yet clarified.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0021-9150
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
80
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
125-34
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2610724-Adenosine Triphosphate,
pubmed-meshheading:2610724-Animals,
pubmed-meshheading:2610724-Aorta, Thoracic,
pubmed-meshheading:2610724-Arteriosclerosis,
pubmed-meshheading:2610724-Cholesterol,
pubmed-meshheading:2610724-Endothelium, Vascular,
pubmed-meshheading:2610724-Energy Metabolism,
pubmed-meshheading:2610724-Female,
pubmed-meshheading:2610724-Hyperlipidemias,
pubmed-meshheading:2610724-Male,
pubmed-meshheading:2610724-Nitric Oxide,
pubmed-meshheading:2610724-Rabbits,
pubmed-meshheading:2610724-Vasodilator Agents
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Endothelium-dependent relaxation, cholesterol content and high energy metabolite balance in Watanabe hyperlipemic rabbit aorta.
|
| pubmed:affiliation |
Dept. of Pharmacology, Padua University, Italy.
|
| pubmed:publicationType |
Journal Article
|