Linked Life Data

2610506

Source:http://linkedlifedata.com/resource/pubmed/id/2610506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1990-2-22
pubmed:abstractText
The pharmacokinetics of cefetamet after a short intravenous infusion of cefetamet (515 mg) and oral administration of 1,000 mg of cefetamet pivoxil were studied in 9 healthy subjects and in 38 patients with various degrees of renal impairment. The results showed that cefetamet elimination was dependent on renal function. After intravenous dosing, total body (CLS), renal (CLR), and nonrenal (CLNR) clearances were linearly related to creatinine clearance (CLCR; r = 0.95, 0.92, and 0.59, respectively). Elimination half-life (t1/2 beta) was prolonged from 2.46 +/- 0.33 h in normal subjects to 29.1 +/- 13.9 h in patients with CLCR of less than 10 ml/min per 1.73 m2. Correspondingly, CLS and CLR decreased from 1.77 +/- 0.27 and 1.42 +/- 0.25 ml/min per kg to 0.14 +/- 0.04 and 0.04 +/- 0.03 ml/min per kg, respectively. The volume of distribution at steady state (0.298 +/- 0.049 liter/kg) for cefetamet was not altered by renal insufficiency (P greater than 0.05). After oral administration, the elimination parameters, t1/2 beta and CLR, were insignificantly different from the intravenous data (P greater than 0.05). Furthermore, the bioavailability (F) of cefetamet pivoxil (45 +/- 13%) was not altered by renal failure (P greater than 0.05). However, maximum concentration in plasma and the time to achieve this value were significantly increased (5.86 +/- 0.74 versus 14.8 +/- 6.14 micrograms/ml and 3.9 +/- 1.1 versus 8.4 +/- 1.7 h, respectively; P less than 0.05). Based on these observations, it is recommended that patients with CLcr of <10 ml/min per 1.73 m2 and between 10 and 39 ml/min per 1.73 m2 be given one-quarter of the normal daily dose either once or twice daily. Patients with CLcr between 40 and 80 ml/min per 1.73 m2 should receive one-half of the normal dose twice daily. For patients with CLcr of <10 ml/min per 1.73 m2, it would be recommended that they receive a normal standard dose as a loading dose on day 1 of treatment.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-2729925, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-3215964, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-3377466, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-3510263, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-3729324, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-3729361, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-3777912, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-3888488, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-427004, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-4428848, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-609192, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-6301740, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-657716, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-7075110, http://linkedlifedata.com/resource/pubmed/commentcorrection/2610506-7255535
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1952-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Pharmacokinetics of intravenous cefetamet and oral cefetamet pivoxil in patients with renal insufficiency.
pubmed:affiliation
Department of Clinical Research, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
pubmed:publicationType
Journal Article