Linked Life Data

2609997

Source:http://linkedlifedata.com/resource/pubmed/id/2609997

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-2-15
pubmed:abstractText
Praziquantel (PQT) is a chiral compound with an asymmetric center at the 11 b-position. The recemic mixture is usually used as an antischistosomal drug, however the antischistosomal activity is mainly concentrated in the R (-)-enantiomer. This study was undertaken to investigate the stereoselectivity of the arrhythmogenic effect of PQT in conscious rabbits. Arrhythmias, as well as bradycardia, were induced in rabbits by iv (+/-) PQT or its enantiomers at 45 mg/kg. The frequency of ectopic rhythms in the (+), (+/-) and (-) PQT groups were 100, 60 and 20%, respectively. Statistically, the frequency of ectopic rhythms in the (+) PQT group was significantly higher than those in the (-) PQT group and in the (+/-) PQT group, although there was no significant difference between the (+/-) and (-) PQT groups. The severity of the arrhythmias induced by (+) PQT was much higher than that induced by (-) PQT. The bradycardia action of (+) PQT was much more intense than that of (-) PQT. (+/-) PQT or its enanthiomers (icv) at a dose of 2 or 3 mg/kg also induced arrhythmias. The frequency of ectopic rhythms in the (+) PQT group was significantly higher than that in the (-) PQT group. The results suggest that there is a stereoselectivity of the arrhythmogenic effects of PQT in rabbits. Arrhythmias induced by PQT may partly mediated via the central nervous system, and the arrhythmogenic effects of (+/-) PQT may be caused mainly by (+) PQT.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0253-9756
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Stereoselectivity of arrhythmogenic effect of praziquantel in conscious rabbits].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't