Linked Life Data

2608638

Source:http://linkedlifedata.com/resource/pubmed/id/2608638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1990-2-9
pubmed:abstractText
Horseradish peroxidase and lanthanum nitrate were used in pregnant guinea-pigs as electron dense tracers to determine whether the 'permeability' characteristics of the uterine epithelium support the hypothesis that immunoglobulin G gains access to the uterine lumen by transepithelial diffusion. Horseradish peroxidase was injected intravenously in eight animals in experiments ranging from 1-43 min and directly into the uterine lumen in five animals in experiments of 1-8 min duration. Lanthanum nitrate was injected only into the uterine lumen of eight animals for exposures of 1-8 min. Horseradish peroxidase did not traverse the junctional complexes regardless of injection site; lanthanum nitrate did not penetrate the complexes either except in one animal. We conclude that the uterine epithelium is a barrier that prevents the diffusional transfer of IgG from mother to fetus. Further studies are required to locate the site where maternal IgG is transferred to the uterine lumen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0143-4004
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-41
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Electron microscopical tracers in the uterine epithelium of the pregnant guinea-pig.
pubmed:affiliation
Department of Biology, Warner Pacific College, Portland, Oregon 97215.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.