Linked Life Data

2605525

Source:http://linkedlifedata.com/resource/pubmed/id/2605525

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-2-12
pubmed:abstractText
Granule cell lesions cause an increase in acetylcholinesterase (AChE) staining in the molecular layer of the dentate gyrus. The source of this response was examined by combining granule cell lesions with lesions of the fornix-fimbria, thereby removing the cholinergic input from the septum to the hippocampus. The increased AChE staining was present in animals with granule cell lesions regardless of whether the fornix was lesioned or intact. The increase in AChE staining occurred without a corresponding increase in choline acetyltransferase staining. These findings suggest that an AChE-positive, but non-cholinergic, sprouting response occurred within the dentate gyrus following selective lesions of the granule cells. The source of this sprouting may be from AChE-positive hilar interneurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
503
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
317-21
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Increase in acetylcholinesterase in the molecular layer of the dentate gyrus in the absence of septal inputs following selective granule cell lesions.
pubmed:affiliation
Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington 05405.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.