Linked Life Data

2605038

Source:http://linkedlifedata.com/resource/pubmed/id/2605038

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1990-2-16
pubmed:abstractText
Human and mouse peritoneal macrophages cultured in the presence of the blood serum of patients with documented coronary heart disease showed a 2- to 3-fold rise in levels of intracellular cholesterol ester and a 1.5- to 2-fold increase in those of free cholesterol and triglycerides. This effect was observed in 83% of cases, whereas the serum of healthy subjects induced the accumulation of lipids in macrophages only in 28% of cases. These data accord with previously published observations obtained on smooth muscle cells of human aortic intima. A direct correlation was found between the accumulation of cholesterol in macrophages and in cultured smooth muscle cells of human aortic intima. The accumulation of lipids in macrophages was dose dependent and increased with time. It is assumed that a culture of peritoneal macrophages may serve as a model for identifying an atherogenic potential of patients' blood serum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0785-3890
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
455-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Peritoneal macrophages: a model for detecting atherogenic potential in patients' blood serum.
pubmed:affiliation
USSR Cardiology Research Center, Academy of Medical Sciences, Moscow.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't