Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1990-2-5
|
pubmed:abstractText |
Serum lipids, lipoproteins, cholesterol absorption and parameters of cholesterol metabolism were related to apolipoprotein E phenotypes in 38 patients with familial xanthomatous hypercholesterolemia. Serum lipids and lipoproteins were similar in 2 most frequent apo E phenotypes E 3/3 and E 4/3. Coronary artery disease was not related to the apo E phenotypes. Cholesterol absorption efficiency was significantly lower in the apo E 3/3 patients than in the apo E 4/3 group. A high serum level of cholesterol precursor lathosterol, a high lathosterol/sitosterol ratio and sterol balance data suggest that cholesterol synthesis may be slightly higher in the apo E 3/3 than E 4/3 group. The findings indicate that the genetically determined apo E polymorphism contributes to cholesterol absorption efficiency in FH patients, but serum total and lipoprotein cholesterol levels are poorly related to apo E isoforms.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sitosterols,
http://linkedlifedata.com/resource/pubmed/chemical/lathosterol
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0021-9150
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
80
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
27-32
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2604754-Apolipoproteins E,
pubmed-meshheading:2604754-Cholesterol,
pubmed-meshheading:2604754-Humans,
pubmed-meshheading:2604754-Hyperlipoproteinemia Type II,
pubmed-meshheading:2604754-Lipids,
pubmed-meshheading:2604754-Lipoproteins,
pubmed-meshheading:2604754-Phenotype,
pubmed-meshheading:2604754-Sitosterols
|
pubmed:year |
1989
|
pubmed:articleTitle |
Apolipoprotein E phenotype and cholesterol metabolism in familial hypercholesterolemia.
|
pubmed:affiliation |
Second Department of Medicine, University of Helsinki, Finland.
|
pubmed:publicationType |
Journal Article
|