Linked Life Data

2602406

Source:http://linkedlifedata.com/resource/pubmed/id/2602406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1990-1-31
pubmed:abstractText
To investigate relationship between aluminium and senile dementia of Alzheimer type (SDAT), hair aluminium concentration was measured by ICP method in 35 cases of SDAT (mean 80 yr.) diagnosed clinically and 71 normal aged volunteers (mean 76 yr.). In normal aged, cerebral blood flow (CBF) also determined by Xe133 inhalation method simultaneously. Mean hair aluminium concentration in SDAT was within normal range of Japanese subjects and significantly lower than that of normal aged controls. There was no significant aging effect to hair aluminium concentration in both groups. Hair calcium and magnesium concentrations were significantly lower in SDAT than that of normal aged. Hair aluminium positively correlated to hair calcium and magnesium in SDAT. Hair aluminium negatively correlated to CBF, and CBF positively correlated to calcium and magnesium concentrations in hair in normal aged. Hair aluminium concentration does not appear to be of use in the diagnosis of SDAT. However, it is undeniable that decreased calcium and magnesium enhance selective accumulation of aluminium in the brain in SDAT. Inverse correlation between hair aluminium and CBF in normal aged suggests that aluminium might have some contribution to aging of the brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-7742
pubmed:author
pubmed:issnType
Print
pubmed:volume
317
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1095-109
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Hair aluminium in normal aged and senile dementia of Alzheimer type.
pubmed:affiliation
3rd Department of Internal Medicine, Shimane Medical University, Japan.
pubmed:publicationType
Journal Article