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pubmed-article:2600669pubmed:abstractTextThe effect of low dietary intake of zinc was studied in six normal infants with the use of 70Zn as an extrinsic tag. Of the two study formulas, one provided a zinc intake similar to that of customary infant formulas ("high" intake), whereas the other provided a "low" zinc intake. Two zinc absorption studies were performed with each formula (sequence: high-low-low-high). Extrinsically labeled formula was fed for 24 h and excreta were collected for 72 h. Zinc isotope ratios were determined by inductively coupled plasma mass spectrometry (ICP/MS). When zinc intake was high, net zinc absorption was 9.1 +/- 8.7% (mean +/- SD) of intake and net zinc retention was 74 +/- 91 micrograms/(kg.d). True zinc (70Zn) absorption was 16.8 +/- 5.8% of intake and fecal excretion of endogenous zinc was 78 +/- 56 micrograms/(kg.d). When zinc intake was low, net absorption of zinc increased significantly (P less than 0.001) to 26.0 +/- 13.0% of intake, but net retention was not significantly different at 42 +/- 33 micrograms/(kg.d). True absorption of zinc also increased significantly (P less than 0.001) to 41.1 +/- 7.8% of intake, whereas fecal endogenous zinc decreased (P less than 0.05) to 34 +/- 16 micrograms/(kg.d) during low zinc intake. Thus, infants maintain zinc balance in the face of low zinc intake through increased efficiency of absorption and decreased excretion of endogenous zinc.lld:pubmed
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pubmed-article:2600669pubmed:authorpubmed-author:ZieglerE EEElld:pubmed
pubmed-article:2600669pubmed:authorpubmed-author:ThompsonJ JJJlld:pubmed
pubmed-article:2600669pubmed:authorpubmed-author:NelsonS ESElld:pubmed
pubmed-article:2600669pubmed:authorpubmed-author:EdwardsB BBBlld:pubmed
pubmed-article:2600669pubmed:authorpubmed-author:SerfassR ERElld:pubmed
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pubmed-article:2600669pubmed:volume119lld:pubmed
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pubmed-article:2600669pubmed:pagination1647-53lld:pubmed
pubmed-article:2600669pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:2600669pubmed:year1989lld:pubmed
pubmed-article:2600669pubmed:articleTitleEffect of low zinc intake on absorption and excretion of zinc by infants studied with 70Zn as extrinsic tag.lld:pubmed
pubmed-article:2600669pubmed:affiliationDept. of Pediatrics, University of Iowa, Iowa City 52242.lld:pubmed
pubmed-article:2600669pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2600669pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:2600669pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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