Linked Life Data

2594916

Source:http://linkedlifedata.com/resource/pubmed/id/2594916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-1-25
pubmed:abstractText
Ethanol (2.95 g/kg, IP) eliminated the righting reflex and induced vigorous tongue clonus spontaneously or following tactile tongue stimulation in Fischer F344 rats. Responses normally lasted 30-60 min, and was reinstated by tactile stimulation in those cases where it subsided quickly. Sub-hypnotic (1.95 g/kg) or high (3.95 g/kg) doses failed to elicit clonus, even after tactile stimulation. A lipophilic alpha 1-adrenergic agonist (St 587) promptly initiated tongue clonus in rats treated with a 3.95 g/kg dose of ethanol. Prazosin, a selective alpha 1-adrenergic antagonist, blocked clonus, while the dopamine selective antagonist pimozide failed to modify this response. We infer an alpha 1-adrenergic effect in which norepinephrine is released by ethanol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
497-500
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Involvement of noradrenergic system in a remarkably rapid tongue clonus produced by acute hypnotic doses of ethanol in Fischer F344 rats.
pubmed:affiliation
Psychopharmacology Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.