Linked Life Data

2593866

Source:http://linkedlifedata.com/resource/pubmed/id/2593866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-1-12
pubmed:abstractText
Early studies performed between 1946 and 1952 reported that cutaneously applied oestrogens had local effects in spite of probable systemic absorption. In order to test the validity of these observations the epidermal effects of topically applied 17 beta-oestradiol (E2) of 8 post-menopausal women were studied in a double-blind placebo-controlled cross-over study using non-invasive bioengineering techniques. E2 or placebo was applied twice daily for 45-50 days in a gel (at concentrations of 0.1 mg/g and 1.0 mg/g) and the results were compared. Changes in epidermal hydration (electrical capacitance and conductance) and mechanical properties were studied. We were unable to confirm the short-term local oestrogenic effects on post-menopausal human skin reported in the earlier studies. Thus, in spite of its high number of oestrogen receptors, the epidermis does not appear to be a target organ for oestrogens under clinical conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0378-5122
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-34
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Short-term effects of topical 17 beta-oestradiol on human post-menopausal skin.
pubmed:affiliation
Department of Dermatology, Rigshospitalet, University of Copenhagen.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial