Linked Life Data

2592165

Source:http://linkedlifedata.com/resource/pubmed/id/2592165

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1990-1-25
pubmed:abstractText
Autoradiography with 3H-adenosine was used to localize cells that accumulate adenosine in the cat retina. Electrophysiologic effects elicited by adenosine on DC-electroretinograms (ERG) and optic nerve responses (ONR) were studied in isolated, arterially perfused cat eyes. Subpopulations of cells localized in the ganglion cell layer and inner nuclear layer showed clear labeling for adenosine. This purine nucleoside enhanced the ERG b-wave and the standing potential; depressed the light peak; and markedly depressed the ONR, in which it reduced the amplitudes of the ON-, plateau-, and OFF-components. A vasodilatory action of adenosine was documented by an increase in perfusion flow rate. Our data suggest that adenosine in cat retina has complex modulatory effects, involving the retinal pigment epithelium, neuronal structures, blood vessels, and probably glial cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2533-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Adenosine: autoradiographic localization and electrophysiologic effects in the cat retina.
pubmed:affiliation
Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
pubmed:publicationType
Journal Article