|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1990-1-25
|
|
pubmed:abstractText |
Two independent lines of evidence support the localization of a schizophrenia susceptibility locus to the proximal long arm of chromosome 5. A partial trisomy of chromosome 5 (5q11.2-q13.3) cosegregates with the disorder in a Canadian family of Chinese descent, and DNA markers from proximal 5q cosegregate with schizophrenia (plus related disorders) in families of British and Icelandic descent. We constructed a human:hamster hybrid cell line (HHW 1064) whose only human complement is a chromosome 5 that is missing the trisomic region associated with schizophrenia. In combination with a "matched" cell hybrid (HHW 105) containing an intact chromosome 5, we physically mapped DNA markers relative to the trisomy. "Schizophrenia-linked" DNA markers p105-153Ra (D5S39) and p105-599Ha (D5S76) map within the trisomy and proximal to the 5q11.2 breakpoint, respectively. The hybrid cell lines HHW 105 and HHW 1064 together provide a means to identify and generate syntenic DNA markers to further investigate the location of a schizophrenia locus.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2725644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2867473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2881276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2886227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2895320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2903449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2903450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2907873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-2991893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-3005988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-3013851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-3020511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-3034481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-3041227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-3479843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-6323448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2591972-7177110
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0888-7543
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
940-4
|
|
pubmed:dateRevised |
2011-8-25
|
|
pubmed:meshHeading |
pubmed-meshheading:2591972-Animals,
pubmed-meshheading:2591972-Chromosome Deletion,
pubmed-meshheading:2591972-Chromosome Mapping,
pubmed-meshheading:2591972-Chromosomes, Human, Pair 5,
pubmed-meshheading:2591972-Cricetinae,
pubmed-meshheading:2591972-Female,
pubmed-meshheading:2591972-Genetic Linkage,
pubmed-meshheading:2591972-Genetic Markers,
pubmed-meshheading:2591972-Humans,
pubmed-meshheading:2591972-Hybrid Cells,
pubmed-meshheading:2591972-Male,
pubmed-meshheading:2591972-Nucleic Acid Hybridization,
pubmed-meshheading:2591972-Pedigree,
pubmed-meshheading:2591972-Schizophrenia,
pubmed-meshheading:2591972-Trisomy
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia.
|
|
pubmed:affiliation |
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
