Linked Life Data

2591175

Source:http://linkedlifedata.com/resource/pubmed/id/2591175

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Suppl
pubmed:dateCreated
1990-1-17
pubmed:abstractText
This study investigated patterns of resistance in anaerobic organisms isolated at Westmead Hospital in Sydney, Australia, during the years 1987 to 1988. Minimal inhibitory concentrations (MICs) to ampicillin, sulbactam/ampicillin, metronidazole, clindamycin, and cefoxitin were determined by agar dilution for 200 anaerobes from clinically significant infections. Antibiotics active against nearly all of these anaerobes included metronidazole and sulbactam/ampicillin, which demonstrated good activity against beta-lactamase producing Bacteroides spp. with the exception of Bacteroides distasonis. Resistance in non-beta-lactamase producing anaerobes was similar to that seen with ampicillin. As expected, ampicillin resistance was common in the Bacteroides fragilis group where beta-lactamase production was frequent. In addition, beta-lactamase was detected in 33% of other Bacteroides spp. Ampicillin resistance was also seen in 5 to 15% of additional anaerobes that did not produce beta-lactamase. Clindamycin resistance occurred in 4 to 18% of the B. fragilis group. Clindamycin resistance was also seen in 7 to 8% of Clostridium spp. and anaerobic Gram-positive cocci. Resistance to cefoxitin was variable in the B. fragilis group with the highest levels of resistance occurring in the indole-negative subgroup. Resistance in other anaerobes was not commonly seen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0732-8893
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159S-163S
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Patterns of resistance to anaerobic organisms in Australia.
pubmed:affiliation
Microbiology Department, Liverpool Hospital, Sydney, Australia.
pubmed:publicationType
Journal Article, In Vitro