| pubmed-article:2587935 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2587935 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2587935 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:2587935 | lifeskim:mentions | umls-concept:C0039097 | lld:lifeskim |
| pubmed-article:2587935 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:2587935 | lifeskim:mentions | umls-concept:C0312586 | lld:lifeskim |
| pubmed-article:2587935 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2587935 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2587935 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2587935 | pubmed:dateCreated | 1989-12-26 | lld:pubmed |
| pubmed-article:2587935 | pubmed:abstractText | Our previous studies demonstrated the presence of a T-cell replacing factor in the synovial fluid (SF) of patients with rheumatoid arthritis (RA) and that RA-SF can activate, selectively, the induction of IgG2b antibody secreting cells in lipopolysaccharide (LPS)-pretreated mouse spleen cell cultures. In the present study the effect of RA-SF was tested in vivo in mice. Injection of the polyclonal activator LPS induced the production of IgM and IgG3 secreting cells in normal mice. However, the addition of RA-SF led to a selective increase in the production of IgG2b with a peak response on day 5 and IgG1 plaque-forming cells (PFC) with a peak on day 7. Neither the IgG2b nor IgG1 responses were caused by specific immunity against heterologous proteins present in RA-SF, as injection of in vitro inactive RA-SF samples did not induce PFC. The effect on B cells of RA-SF was further evaluated by injection of RA-SF in combination with LPS to the Xid B-cell deficient CBA/N mice. RA-SF had identical effects in CBA/N as in normal mice. The biological implication of these findings is discussed. Our earlier results support the idea that B cells are endogenously activated in RA patients. We have speculated that this activation is caused by the B-cell differentiation factor which is present in SF. Therefore, we also tested whether RA-SF could influence antibody-forming cells in mice that spontaneously develop autoimmunity. We found that injection of RA-SF alone, in the absence of any other activating substance, induced a very marked increase of IgG producing cells in (NZW x NZB) F1 hybrid mice. From a relatively high background level the RA-SF could still induce an up to 100-fold increase in the numbers of PFC in spleens of such mice. | lld:pubmed |
| pubmed-article:2587935 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2587935 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2587935 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2587935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2587935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2587935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2587935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2587935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2587935 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2587935 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2587935 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:2587935 | pubmed:author | pubmed-author:MöllerEE | lld:pubmed |
| pubmed-article:2587935 | pubmed:author | pubmed-author:StrömHH | lld:pubmed |
| pubmed-article:2587935 | pubmed:author | pubmed-author:Abedi-Valuger... | lld:pubmed |
| pubmed-article:2587935 | pubmed:author | pubmed-author:RidderstadAA | lld:pubmed |
| pubmed-article:2587935 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2587935 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:2587935 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2587935 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2587935 | pubmed:pagination | 587-96 | lld:pubmed |
| pubmed-article:2587935 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
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| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:meshHeading | pubmed-meshheading:2587935-... | lld:pubmed |
| pubmed-article:2587935 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2587935 | pubmed:articleTitle | Synovial fluid from rheumatoid arthritis patients induces polyclonal antibody formation in vivo. | lld:pubmed |
| pubmed-article:2587935 | pubmed:affiliation | Department of Immunology, University of Stockholm, Sweden. | lld:pubmed |
| pubmed-article:2587935 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2587935 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
