Linked Life Data

2587117

Source:http://linkedlifedata.com/resource/pubmed/id/2587117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-1-4
pubmed:abstractText
When cardiac output is critically lowered, whole body O2 consumption decreases and an O2 deficit accumulates. With restoration of cardiac output, an excess O2 consumption is expected in order to "repay" some or all of the O2 deficit. We tested the hypothesis that young lambs, with higher resting O2 consumption, cardiac output and growth rates than older lambs, would repay less of their O2 deficit because they have a higher proportion of nonessential metabolism. We reduced cardiac output acutely by inflating a Foley catheter in the right atrium of spontaneously breathing, sedated lambs at ages 2 (n = 5) and 8 (n = 5) wk. Each lamb was studied with low cardiac output periods of 30 and 60 min on different days. Aortic and pulmonary artery blood pressures, gases, and O2 saturations, venous Hb, and arterial lactate concentrations were measured every 10 min during baseline, low output, and 60 min of recovery. Oxygen consumption was monitored continuously. Oxygen deficit and excess O2 of recovery were calculated from the time integral of the difference between O2 consumption at baseline and during the respective study period. The average percent decreases in cardiac output (66.4 and 64.6%) and O2 consumption (38.1 and 35.1%) were similar in the 2- and 8-wk groups, respectively. There was no consistent relation between O2 deficit and O2 repayment in either age group. However, on average the 2-wk group repaid a significantly lower percentage (3 +/- 16%, mean +/- SEM) than 8-wk-olds (76 +/- 29%).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
180-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Response to low cardiac output: developmental differences in metabolism during oxygen deficit and recovery in lambs.
pubmed:affiliation
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't