| pubmed-article:2586524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C0025545 | lld:lifeskim |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C0036488 | lld:lifeskim |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:2586524 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:2586524 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2586524 | pubmed:dateCreated | 1990-1-11 | lld:pubmed |
| pubmed-article:2586524 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2586524 | pubmed:abstractText | The metallothionein-A gene in the metallothionein gene family of the sea urchin Strongylocentrotus purpuratus (SpMTA gene) was sequenced and found to contain three coding exons plus a 3' entirely noncoding exon. Putative alpha and beta MT domains were encoded, by its exons 2 and 3, respectively, in reverse of the order in vertebrate metallothionein genes. The SpMTA promoter was characterized through the expression of recombinant constructs containing various portions of the proximal 678-base-pair (bp) 5'-flanking region of the SpMTA gene. Zygotes injected with constructs were cultured to the blastula stage in the presence of a heavy-metal chelator and then incubated in the presence or absence of cadmium. The longest constructs were expressed only when heavy-metal ion was present. Two putative metal-responsive elements (MREs a and b) within 240 bp of the transcription start site resembled mammalian MREs in their critical 8-bp cores (TGCRCNCS) and in their locations relative to each other and to the TATA box. Elimination of activity by site-specific mutations in MREs a and b, separately or in both, identified them as metal regulatory elements. Thus, MRE recognition in this invertebrate resembles that in vertebrates. Upstream sites with single-mismatched MREs neither acted as MREs nor amplified the activity of MREs a and b. The SpMTA, Spec1, and CyIIIa actin genes, which have the same ectodermal specificity, have common DNA elements at relatively similar locations in their promoter regions; however, these elements are insufficient in themselves to promote gene expression. | lld:pubmed |
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| pubmed-article:2586524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2586524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2586524 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2586524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2586524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2586524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2586524 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2586524 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2586524 | pubmed:author | pubmed-author:NemerMM | lld:pubmed |
| pubmed-article:2586524 | pubmed:author | pubmed-author:ThorntonR DRD | lld:pubmed |
| pubmed-article:2586524 | pubmed:author | pubmed-author:WatkinsEE | lld:pubmed |
| pubmed-article:2586524 | pubmed:author | pubmed-author:HarlowPP | lld:pubmed |
| pubmed-article:2586524 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2586524 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:2586524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2586524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2586524 | pubmed:pagination | 5445-55 | lld:pubmed |
| pubmed-article:2586524 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2586524 | pubmed:meshHeading | pubmed-meshheading:2586524-... | lld:pubmed |
