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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1990-1-2
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|
pubmed:abstractText |
Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implications of these findings for passive antibody therapy of septic shock are discussed.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0092-6213
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
29
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
93-106
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:2582583-Adult,
pubmed-meshheading:2582583-Anti-Bacterial Agents,
pubmed-meshheading:2582583-Antibodies, Bacterial,
pubmed-meshheading:2582583-Endotoxins,
pubmed-meshheading:2582583-Female,
pubmed-meshheading:2582583-Humans,
pubmed-meshheading:2582583-Immunoglobulin G,
pubmed-meshheading:2582583-Lipopolysaccharides,
pubmed-meshheading:2582583-Male,
pubmed-meshheading:2582583-Pneumococcal Infections,
pubmed-meshheading:2582583-Shock, Septic,
pubmed-meshheading:2582583-Time Factors
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|
pubmed:year |
1989
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|
pubmed:articleTitle |
Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock.
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|
pubmed:affiliation |
S.E. Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh, UK.
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|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
